Sometime in the near future, paraplegic prison inmate Matt Mills meets "The Board" of Satoshi-Telefair Industries, who thank him for joining the Program. Under pressure and with a promise to make him walk again, Mills agrees to volunteer. He is injected with a synthetic nanomaterial and suffocated, only to wake up with restored use of his legs, yet alone in a steel cell in the first spoke of an experimental apparatus - The Wheel. A series of assailants inflict a multitude of damage to Mills' body and torment his mind, yet the synthetic nanomaterial not only restores his damaged organs, it re-engineers his strength. The experiment might be designed to kill, but Mills is determined to survive - and get back to his daughter before The Board finds her first.

帕特里克昏昏欲睡在一家小型私立医院，他唯一的举动是非自愿地随地吐痰。当一个刚与丈夫分开的年轻护士开始在医院工作时，她感觉到帕特里克正在与她交流，他似乎正在利用自己的心理力量来操纵她生活中的事件。